Comprehensive Genomic Profiling (CGP)

CGP is an approach that utilizes next-generation sequencing (NGS) to assess multiple established biomarkers present within a solid tumor. CGP detects at a genomic resolution that allows identification of variant classes such as SNVs, indels, CNVs, select fusions, as well as cancer genomic signatures such as tumor mutational burden (TMB) and microsatellite instability (MSI).

The breadth of this single assay allows for a robust understanding of a tumor profile alleviating the need to use multiple tumor specific panels or different modalities of testing.

KEY BENEFITS

Comprehensive updated biomarkers in a single assay

  • Includes 562 genes which incorporates all major tumor types
  • Can enable detection of SNV, CNV, TMB, and select fusions and MSI

Based in clinical research

  • Enables research with recently updated biomarkers from tumor testing guidelines, such as ESCO, ASCO, and NCCN.
  • CGP is increasingly adopted for the utilization of post-therapy guidance biomarker analysis

Customizable for your needs and sample population

  • Breadth of coverage for key biomarkers
  • Customer centric content customization capabilities with integrated desired analysis solutions
  • Sequencer Agnostic Workflow

Tumor Sequencing

"At LifeStrands Genomics Australia, we rely heavily on Twist’s NGS probes and reagents across nearly all our assays... Twist’s probe design flexibility and scalability have allowed us to tailor both DNA and RNA panels that suit a wide range of solid tumours without compromising sensitivity or turnaround times. We view Twist not just as a vendor, but as a strategic partner in advancing precision oncology. ”

* The results are specific to the institution to which they were obtained. The results presented are customer-specific and should not be interpreted as indicative of performance across all institutions.

Dr. Vivek Rathi, MD MSc FRCPA
Medical Director
LifeStrands Genomics Australia
(Genoox User) 

Complete Solution Set for Solid Tumor DNA Analysis

Sequencing

Compatible solutions to sequence on your preferred platform

Twist Oncology DNA CGP panel can be paired with our modular reagent solutions to enable platform compatibility.

Analysis Options

Analysis solutions to meet you lab’s needs

Twist offers a variety of bioinformatic solutions for CGP analysis.

Broad Coverage of Tumor Types

Twist’s DNA CGP panel covers a broad set of solid tumor types and associated mutations enabling a single panel to be utilized across many tissue types. For a complete listing of all genes, SNPs, and hotspots covered by the panel, please refer to the technical documents in the resources tab or click download button in the sidebar.

The DNA CGP panel is designed to cover mutations such as single nucleotide variants (SNVs), Insertions and deletions (InDels), and copy number alterations and gene rearrangements. Additional genomic signatures scoring such as tumor mutational burden (TMB) and  microsatellite instability (MSI) is available when combined with Twist’s bioinformatic analysis solution, or a 3rd party analysis software.

Want to see what’s included in the panel?

Click the button below to download the contents of this panel including the genes covered.

Twist Oncology DNA Comprehensive Genomic Panel (CGP) Product Sheet
Twist Universal Adapter Systems Product Sheet
Twist Full Length Unique Dual Index (UDI) Adapters

Comprehensive Genomic Profiling (CGP) Panel .bed files
Twist Oncology DNA Comprehensive Genomic Panel (CGP) Gene List
HT UDI Sequences Reference Sheet and Sample Sheet Templates
UDI Sequences Reference Sheet and Sample Sheet Templates
Full Length UDI Adapters Reference Spreadsheet and Sample Sheet Template

DNA CGP Panel using QIAGEN® CLC Genomics    Workbench Application Note

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